1. Thailand Antimicrobial Resistant Organisms Database (TAROD)

The Thailand Antimicrobial Resistant Organisms Database (TAROD) serves as a nationwide genomic repository for antimicrobial-resistant bacteria collected from clinical facilities and environmental settings. Originally established to catalogue carbapenem-resistant Acinetobacter baumannii, the platform is being expanded to encompass additional high-priority drug-resistant pathogens. By integrating genomic data from human, animal, and environmental sources, TAROD enables real-time surveillance and cross-sectoral monitoring of antimicrobial resistance within a One Health framework.

2. Polycationic polymer-based nanoplatform for antimicrobial compound delivery

In this research project, we aim to develop a cationic polymer nanocomplex capable of binding to and delivering antimicrobial agents. Such a nanocarrier offers several scientific advantages. Its nanoscale particle size facilitates penetration through bacterial cell envelopes, allowing the therapeutic cargo to reach intracellular targets more effectively. Moreover, the positively charged micellar surface enhances electrostatic interactions with the negatively charged outer membrane of bacteria, thereby promoting more efficient attachment and uptake.

3. Prebiotics, Probiotics, and Postbiotics for Combating Antimicrobial Resistance

AMRIC Thailand investigates prebiotic, probiotic, and postbiotic approaches as innovative, non-antibiotic strategies to combat antimicrobial resistance (AMR). Research on prebiotics focuses on dietary substrates that selectively enrich beneficial gut microbes, reducing colonization by multidrug-resistant pathogens. Probiotic projects develop live microbial formulations that inhibit resistant bacteria, modulate host immunity, and limit horizontal gene transfer of resistance genes. Studies on postbiotics evaluate cell-free metabolites and bioactive compounds from probiotic cultures for their ability to suppress AMR organisms and strengthen epithelial barrier function.

4. Phage Therapy for Antimicrobial Resistance

Phage therapy uses bacteriophages to target and kill drug-resistant bacterial strains. It is being explored as a solution to combat AMR, especially for infections caused by E. coli and Acinetobacter baumannii. Research shows that phages can work alone or with antibiotics to improve treatment outcomes and reduce biofilm-associated resistance.

5. Plant-Derived Compounds for Antimicrobial Resistance

Plant-derived compounds, such as flavonoids, terpenes, and alkaloids, exhibit antimicrobial activity against resistant bacteria. Many of these compounds can disrupt biofilm formation or break down existing biofilms, which are key factors in chronic and hard-to-treat infections. By targeting both bacterial cells and biofilms, plant-based agents offer promising support in overcoming AMR.